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pentobarbital will lessen the extent or effect of cobimetinib by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Steer clear of coadministration. Solid or moderate CYP3A inducers may reduce cobimetinib systemic publicity by >80% and lower its efficacy.pentobarbital decreases levels of ponatinib by influencing hepatic/intesti